1054. Hematopoietic and Non-Hematopoietic Engraftment after Bone Marrow Transplantation in Newborn Mice

Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism.

Organ allografts have been shown to provide a syngeneic microenvironment for organ-based donor hematopoietic stem cells to maintain long-lasting chimerism after transplantation. We hypothesized that organ allografts would also support engraftment and hematopoiesis of adjunctively infused donor marrow stem cells, syngeneic to organ grafts, in nonmyeloablated recipients. In BN-to-LEW and GFP-to-A...

Bone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation

The bone marrow is the origin of all hematopoietic lineages and an important homing site for memory cells of the adaptive immune system. It has recently emerged as a graft-versus-host disease (GvHD) target organ after allogeneic stem cell transplantation (alloHSCT), marked by depletion of both hematopoietic progenitors and niche-forming cells. Serious effects on the restoration of hematopoietic...

Optimizing hematopoietic recovery following bone marrow transplantation.

Blood cell production is a dynamic process in which immature precursors progress through a series of developmental events that culminate in the production of mature cells of the erythroid, myeloid, and lymphoid lineages. The characteristics of cells at particular stages of development and the intrinsic and extrinsic signals that regulate their growth and differentiation are becoming increasingl...

Failure Marrow Transplantation after Engraftment Promotes Engraftment for Secondary Bone Primary Bone Marrow Transplantation

Immunologic and hematopoietic effects of CD40 stimulation after syngeneic bone marrow transplantation in mice.

CD40 is a molecule present on multiple cell types including B lymphocyte lineage cells. CD40 has been shown to play an important role in B cell differentiation and activation in vitro, although little is known concerning the effects of CD40 stimulation in vivo. We therefore examined the effects of CD40 stimulation in mice using a syngeneic bone marrow transplantation (BMT) model in an effort to...